Compositions and methods for the therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/31 (2006.01) A61K 39/05 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07K 14/195 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 9/10 (2006.01) C12N 9/20 (2006.01) C12N 9/24 (2006.01) C12N 9/50 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2407352

Compositions and methods for the therapy and diagnosis of acne vulgaris and other related conditions are disclosed. Compositions may comprise one or more Propionibacterium acnes proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antibody that binds a Propionibacterium acnes protein, antigen presenting cell that expresses a Propionibacterium acnes protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and/or treatment of acne.

L'invention concerne les compositions et les procédés pour la thérapie et le diagnostic de l'acné vulgaire et d'autres états apparentés. Les compositions peuvent comprendre une ou plusieurs protéines de Propionibacterium acnes, des fractions immunogènes de celles-ci, ou des polynucléotides qui codent de telles fractions. Selon une variante, une composition thérapeutique peut comprendre un anticorps qui fixe une protéine de Propionibacterium acnes, une cellule présentant un antigène qui exprime une protéine de Propionibacterium acnes, ou une cellule T qui agit spécifiquement sur les cellules exprimant une telle protéine. De telles compositions peuvent être utilisées, par exemple, pour la prévention et/ou le traitement de l'acné.

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