C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2242340
Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
L'invention concerne des compositions et des procédés pour la détection et le traitement du cancer du sein. Les composés décrits comprennent des séquences nucléotidiques exprimées de préférence dans les tissus de la tumeur du sein, ainsi que des polypeptides codés par de telles séquences nucléotidiques. L'invention concerne également des vaccins et des compositions pharmaceutiques renfermant de tels composés et pouvant s'utiliser, par exemple, pour la prévention et le traitement du cancer du sein. Les polypeptides peuvent également s'utiliser pour la production d'anticorps, lesquels sont utiles pour diagnostiquer et suivre l'évolution du cancer du sein chez une patiente.
Frudakis Tony N.
Reed Steven G.
Smith John M.
Corixa Corporation
Gowling Lafleur Henderson Llp
LandOfFree
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