Compositions and methods for the treatment of tumor

Details Compositions and methods for the treatment of tumor Compositions and methods for the treatment of tumor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15

Patent

CA 2365610

The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

L'invention concerne des compositions et des proc~d~s destin~s au diagnostic et au traitement de croissance cellulaire n~oplasique et ~ la prolif~ration cellulaire chez les animaux, y compris chez l'homme. Elle est bas~e sur l'identification de g­nes qui sont amplifi~s dans le g~nome de cellules tumorales. Une telle amplification de g­nes est normalement associ~e ~ la surexpression d'un produit de g­ne, en comparaison ~ des cellules normales d'un mÚme type de tissu, et elle contribue ~ la formation de tumeurs. Il s'ensuit que les prot~ines cod~es par les g­nes amplifi~s sont cens~es constituer des cibles utiles pour le diagnostic et/ou le traitement (pr~vention comprise) de certains cancers, et qu'elles peuvent agir en tant qu'annonciateurs de pronostic de traitement de tumeur. L'invention concerne donc des polypeptides et des mol~cules d'acides nucl~iques codant pour ces polypeptides. Elle concerne aussi des vecteurs et des cellules hÙtes contenant ces s~quences d'acides nucl~iques, des mol~cules polypeptidiques chim­res comprenant les polypeptides de l'invention fusionn~s ~ des s~quences de polypeptide h~t~rologue, des anticorps qui se lient aux polypeptides de l'invention ainsi que des proc~d~s de production de ces polypeptides.

Affiliated with

Also associated with

Rating

Compositions and methods for the treatment of tumor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for the treatment of tumor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for the treatment of tumor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1698960