A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/12 (2006.01) A61K 31/74 (2006.01)
Patent
CA 2633489
The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug which can treat various dermatological conditions, such as a bacterial infection, a virus infection, a fungal infection, alopecia, dermatitis, psoriasis, or photo damaged skin. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained period of time. The non-volatile solvent system can also act as a plasticizer for the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
La présente invention concerne la solidification de formulations adhésives, des procédés d'administration de médicaments, et des couches solidifiées pour l'administration dermique d'un médicament qui peut traiter diverses conditions dermatologiques, telles qu'une infection d'origine bactérienne, une infection d'origine fongique, l'alopécie, la dermatite, le psoriasis, ou la peau endommagée par le rayonnement solaire. La formulation peut comporter un médicament, un support à base de solvant, et un agent de solidification. Le support à base de solvant peut comporter un système solvant volatile comprenant au moins un solvant volatile, et un système solvant non volatile comprenant au moins un solvant non volatile. Le système solvant non volatile peut faciliter l'administration du médicament à des taux efficaces pour une période de temps prolongée. Le système solvant non volatile peut également agit comme plastifiant. La formulation peut présenter une viscosité appropriée pour une application à la surface de la peau préalablement à l'évaporation du système solvant volatile. Lors de son application sur la peau, la formulation peut former une couche solidifiée après l'évaporation d'au moins une partie du système solvant volatile.
Sharma Sanjay
Warner Kevin S.
Zhang Jie
Ridout & Maybee Llp
Zars Pharma Inc.
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