C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/10 (2006.01) A61K 31/675 (2006.01) A61K 31/7064 (2006.01) C07H 19/20 (2006.01)
Patent
CA 2477241
The present invention relates to mononucleoside phosphate compoundsthat have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified byattaching a degradation resistant substituent on the terminal phosphate of apolyphosphate mononucleotide. By attaching this degradation resistant substituent,the stability from degradation matches or exceeds those of certain dinucleotides.
La présente invention concerne des composés de phosphates mononucléosidiques, qui possèdent les avantages d'un produit pharmaceutique dinucléotidique. Ces phosphates mononucléosidiques peuvent être obtenus à partir d'un mononucléotide qui a été modifié par fixation d'un substituant résistant à la dégradation sur le phosphate terminal d'un mononucléotide polyphosphaté. Grâce à la fixation de ce substituant résistant à la dégradation, la stabilité par rapport à la dégradation est égale ou supérieure à celle de certains dinucléotides.
Brown Edward G.
Crean Christopher S.
Douglass James G. III
Peterson Ward M.
Shaver Sammy Ray
Gowling Lafleur Henderson Llp
Inspire Pharmaceuticals Inc.
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