A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/355 (2006.01) A61K 31/415 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2597329
The present invention concerns methods and compositions involving MDA-7 protein or an MDA-7-encoding nucleic acid in combination with either 1) a COX- 2 selective inhibitor, such as celecoxib, 2) an Hsp90 inhibitor, such as geldanamycin, or a geldanamycin derivative or analog, 3) a vitamin E compound, for the treatment of cancer, 4) a TNF, such as TNF-alpha, 5) a VEGF inhibitor, or 6) an inhibitor of IL-IO. In certain examples, a treatment for breast cancer is provided. In other examples a treatment for lung cancer is provided. Such examples involve, in some cases, an adenovirus vector that expresses MDA- 7 protein.
La présente invention concerne des méthodes et des compositions faisant intervenir la protéine MDA-7 ou l'acide nucléique codant pour MDA-7 en combinaison avec soit 1) un inhibiteur sélectif de COX-2, tel que celecoxib, 2) un inhibiteur de Hsp90 tel que la geldanamycine, ou un dérivé de geldanamycine ou analogue, 3) un composé de vitamine E, pour le traitement du cancer, 4) un TNF, tel que TNF-alpha, 5) un inhibiteur de VEGF, ou 6) un inhibiteur de IL-IO. Dans certains exemples, l'invention concerne un traitement du cancer du sein; dans d'autres, un traitement du cancer du poumon. Ces exemples impliquent dans certains cas un vecteur d'adénovirus qui exprime la protéine MDA-7.
Hunt Kelly K.
Pataer Abujiang
Ramesh Rajagopal
Shanker Manish
Suh Young-Jin
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
LandOfFree
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