Compositions as adjuvants to improve immune responses to...

A - Human Necessities – 61 – K

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A61K 51/00 (2006.01)

Patent

CA 2560941

The invention provides compositions containing an antigen and a TIM targeting molecule. The invention additionally provides a TIM targeting molecule conjugate, for example, a TIM targeting molecule targeted to a therapeutic or diagnostic moiety. The invention additionally provides methods of using such compositions. In one embodiment, the invention provides a method of stimulating an immune response in an individual by administering a composition comprising an antigen and a TIM targeting molecule in a pharmaceutically acceptable carrier. In another embodiment, the invention provides a method of stimulating an immune response in an individual by administering an antigen and a TIM targeting molecule, which can be administered together in a single composition or separately.

L'invention concerne des compositions contenant un antigène et une molécule de ciblage TIM. De plus, l'invention concerne un conjugué de molécule de ciblage, par exemple une molécule de ciblage TIM ciblée sur une fraction thérapeutique ou diagnostique. Cette invention porte en outre sur des méthodes d'utilisation de telles compositions. Dans un mode de réalisation, l'invention concerne une méthodes visant à stimuler une réponse immunitaire chez un individu par l'administration d'une composition renfermant un antigène et une molécule de ciblage TIM dans un véhicule acceptable au plan pharmaceutique. Dans un autre mode de réalisation, l'invention concerne une méthode propre à stimuler un réponse immunitaire chez un individu par l'administration d'un antigène et d'une molécule de ciblage TIM soit dans une seule et même composition, soit séparément.

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