Compositions comprising anrnox-inhibitors for the inhibition...

A - Human Necessities – 61 – K

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Details

A61K 31/7034 (2006.01) A61K 31/166 (2006.01) A61K 31/60 (2006.01) A61K 31/609 (2006.01) A61K 36/896 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2719833

The invention relates to agents for sequestering serum aging factors, and methods for using the same. More partic-ularly, the invention relates to agents termed herein 'Naractin' to denote any one of several naturally-occurring arNOX inhibitors either present in N. tazetta powder or capable of augmenting N. tazetta powder to an inhibitory level comparable to that of the fresh N. tazetta extracts, and to methods for using 'Naractins' to prevent or treat disorders and complications of disorders resulting from cell damage caused by an aging-related isoform of NADH oxidase (arNOX). In one exemplary embodiment the agents of the invention comprise at least one naturally occurring Naractin. Such naturally occurring naratins are also capable of augmenting the anti-arNOX effect of other naturally occurring arNOX inhibitory agents.

La présente invention concerne des agents destinés à séquestrer des facteurs de vieillissement de sérum, et des procédés dutilisation de ceux-ci. Plus particulièrement, linvention concerne des agents appelés ici « naractin » afin de désigner lun quelconque des nombreux inhibiteurs arNOX naturels présents dans la poudre de N. tazetta ou capables délever le niveau dinhibition de la poudre de N. tazetta à un niveau comparable à celui des extraits de N. tazetta frais. Linvention concerne également des procédés dutilisation de « naractins » destinés à empêcher ou à traiter des troubles et des complications de troubles résultant de lésions cellulaires provoquées par un isoforme lié au vieillissement de loxydase NADH (arNOX). Dans un mode de réalisation exemplaire, les agents de la présente invention comprennent au moins un naractin naturel. De tels naractins naturels sont également capables daugmenter leffet anti-arNOX dautres agents dinhibition darNOX naturels.

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