C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/10 (2006.01) A01N 43/90 (2006.01) A61K 31/365 (2006.01) A61P 33/00 (2006.01)
Patent
CA 2684926
Provided is a novel ivermectin derivative and compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (A) a pharmaceutically effective amount of a 1-N-phenylpyrazole compound; (B) a pharmaceutically effective amount of an ivermectin derivative of formula (II) wherein: R14 represents -(CH2)S-O-Z wherein, s is 1 or 2; Y represents -CH(OR, 15)-, -C(=O)- or -C(=NOR 15); R15 represents hydrogen, alkyl or phenyl; and R16 represents -CH3 or -CH2CH3; Z is alkyl, alkenyl, alkynyl, acyl, alkylalkoxy, aryl, alkanoyloxy, alkoxycarbonyl, alkenoyl, alkynoyl, or aroyl.
L'invention porte sur un nouveau dérivé d'ivermectine et sur des compositions pour le traitement et la prophylaxie d'infestations parasites dans des mammifères ou des oiseaux, qui comprennent: (A) une quantité pharmaceutiquement efficace d'un composé 1-N-phénylpyrazole; (B) un composé pharmaceutiquement efficace d'un dérivé d'ivermectine de formule (II) dans lequel: R14 représente -(CH2)S-O-Z où s est 1 ou 2; Y représente -CH(OR15)-, -C(=O) ou -C(=NOR15); R15 représente hydrogène, alkyle ou phényle; et R16 représente -CH3 ou -CH2CH3; Z représente alkyle, alcényle, alcynyle, acyle, alkylalcoxy, aryle, alcanoyloxy, alcoxycarbonyle, alcénoyle, alcynoyle ou aroyle.
Boeckh Albert
Shub Natalya
Soll Mark D.
Merial Limited
Smart & Biggar
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