Compositions comprising organic compounds

Details Compositions comprising organic compounds Compositions comprising organic compounds

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2546244

The present invention relates to pharmaceutical compositions for sustained release comprising as active ingredient an HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof, said composition comprising a core consisting of an inner phase (internal) and an outer phase (external) wherein the outer phase does not comprise a matrix former and wherein the core is first coated with a non functional film coat and then with an enteric coat.

L'invention concerne des compositions pharmaceutiques à libération soutenue contenant comme principe actif un inhibiteur de l'HMG-CoA réductase ou un sel pharmaceutiquement acceptable de celui-ci. La composition selon l'invention contient un noyau constitué d'une phase interne (intérieure) et d'une phase externe (extérieure), la phase externe ne contenant pas d'agent de formation de matrice, le noyau étant d'abord revêtu par un film non fonctionnel, puis par un revêtement gastrorésistant.

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