Compositions for potentiating apoposis signals in tumour cells

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/15 (2006.01) A61K 31/05 (2006.01) A61K 31/337 (2006.01) A61K 31/454 (2006.01) A61K 31/475 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2745795

The present invention concerns a composition for potentiating formation of DISC (Death Inducing Signaling Complex) macro-complex and for inducing apoptotic signal mediated by death receptors in tumour cells comprising a therapeutically effective amount of an active agent selected among a hypocalcemia-inducing agent, a calcium channel inhibitor and a calcium chelator in association with a therapeutically effective amount of an anticancer agent inducing an apoptotic signal via death receptors Fas, TNF-R1, DR4 and/or DR5.

La présente invention concerne une composition destinée à potentialiser la formation du macrocomplexe de signalisation de lapoptose, le DISC (Death Inducing Signaling Complex), et à induire un signal apoptotique médié par les récepteurs apoptotiques dans des cellules tumorales. La composition contient une quantité thérapeutiquement efficace dun principe actif choisi parmi un agent inducteur dhypocalcémie, un inhibiteur des canaux calciques et un chélateur de calcium en association avec une quantité thérapeutiquement efficace dun agent anticancéreux induisant un signal apoptotique par le biais des récepteurs apoptotiques Fas, TNF-R1, DR4 et/ou DR5.

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