Compositions monovalent for cd28 binding and methods of use

Details Compositions monovalent for cd28 binding and methods of use Compositions monovalent for cd28 binding and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01)

Patent

CA 2731220

Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for bind-ing of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin vari-able domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 ac-tivity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antag-onizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

L'invention concerne des anticorps à domaine qui se lient de manière monovalente au CD28. Des anticorps à domaine qui sont monovalents pour la liaison avec le CD28 peuvent inhiber l'activité de CD28. Selon un premier aspect, un anticorps à domaine est constitué ou comprend un domaine variable d'immunoglobuline unique qui se lie spécifiquement au CD28 et oppose son activité, selon un aspect, sans sensiblement opposer l'activité de CD28. Selon un autre aspect, l'anticorps à domaine est un anticorps à domaine humain. La description concerne en outre des procédés pour contrer des interactions de CD80 et/ou CD86 avec CD28 chez un individu, et des procédés de traitement de maladies ou troubles impliquant des interactions de CD80 et/ou CD86 avec CD28, les procédés impliquant l'administration d'un anticorps à domaine à l'individu.

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