Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 251/48 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 239/02 (2006.01) C07D 403/00 (2006.01)

Patent

CA 2539339

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGF.beta. , KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.

L'invention porte sur une nouvelle classe de composés et sur des préparations pharmaceutiques les contenant, et sur leurs méthodes d'utilisation pour traiter ou prévenir des maladies ou troubles associés à une activité anormale ou déréglée de kinases, et en particulier de maladies ou troubles liés à une activité anormale des kinases, Abl, BCR-Abl, EGF-R, c-erbB2 (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGF?, KDR, c-Kit, b-RAF, c-RAF, FLT1 et/ou FLT4.

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