C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2268036
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
Cette invention porte sur des composés et des procédés servant à diagnostiquer la tuberculose. Les composés de l'invention comprennent des polypeptides contenant au moins une partie antigénique d'une ou plusieurs protéines de M. tuberculosis et des séquences d'ADN codant lesdits polypeptides. Des trousses de diagnostic contenant lesdits polypeptides ou séquences d'ADN et un réactif de dépistage approprié peuvent être utilisés pour dépister une infection M. tuberculosis chez des patients ou dans des échantillons biologiques. L'invention porte aussi sur des anticorps dirigés contre lesdits polypeptides.
Campos-Neto Antonio
Dillon Davin C.
Houghton Raymond
Lodes Michael J.
Reed Steven G.
Corixa Corporation
Osler Hoskin & Harcourt Llp
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