C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2230927
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis secretory or non-secretory proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
Composés et méthodes de diagnostic de la tuberculose. Les composés décrits sont notamment des polypeptides contenant au moins une partie antigénique d'une ou de plusieurs protéines sécréteuse ou non sécréteuse de M. tuberculosis, ainsi que les séquences d'ADN codant ces polypeptides. Des trousses de diagnostic contenant ces polypeptides ou séquences d'ADN et un réactif de détection adapté peuvent être utilisés pour la détection de l'infection par M. tuberculosis chez un patient ou dans des échantillons biologiques. Les anticorps dirigés contre ces polypeptides sont également décrits.
Campos-Neto Antonio
Dillon Davin C.
Houghton Raymond
Reed Steven G.
Skeiky Yasir A. W.
Corixa Corporation
Gowling Lafleur Henderson Llp
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