Compounds and methods for modulating activation of nf-.kappa.b

Details Compounds and methods for modulating activation of nf-.kappa.b Compounds and methods for modulating activation of nf-.kappa.b

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) A61K 31/70 (2006.01) A61K 38/53 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2354153

Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.

Cette invention concerne des compositions et des m~thodes permettant de moduler l'activation du facteur nucl~aire .kappa.B (NF-.kappa.B). Ces compositions comprennent au moins un agent qui module l'ubiquitination de I.kappa.B.alpha. et/ou I.kappa.B.beta. phosphoryl~. Ces compositions peuvent Útre utilis~es dans le traitement de maladies associ~es ~ l'activation de NF-.kappa.B. Les agents de modulation comprennent des ubiquitine ligases E3 humaines, des anticorps dirig~s contre lesdites ligases et des variantes desdites ligases, de mÚme que des prot~ines associ~es.

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