Compounds containing a fused bicyclic ring and processes...

Details Compounds containing a fused bicyclic ring and processes... Compounds containing a fused bicyclic ring and processes...

C - Chemistry, Metallurgy

12

P

C12P 13/04 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07C 227/20 (2006.01) C07C 229/22 (2006.01) C07C 319/14 (2006.01) C07C 319/20 (2006.01) C07C 327/34 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07F 9/547 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01) C07C 317/50 (2006.01) C07C 323/59 (2006.01)

Patent

CA 2124375

Compounds of the formula (See formula I) wherein X is O or S-(O)t; n is one or two; m is zero or one; Y is CH2, O, or S-(O)t provided that Y is O or S-(O)t only when m is one; and A is (See formula II or III) are dual inhibitors of NEP and ACE. Compounds wherein A is (See formula IV or V) are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.

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