C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/068 (2006.01) A61K 31/336 (2006.01) A61K 31/404 (2006.01) A61K 38/05 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 303/32 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01)
Patent
CA 2657213
One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain embodiments, the invention relates to the treatment of immune related diseases, comprising administering a compound of the invention. In certain embodiments, the invention relates to the treatment of cancer, comprising administering a compound of the invention.
La présente invention concerne, dans un aspect, des inhibiteurs qui inhibent l'activité immunoprotéasome de manière préférentielle par rapport à l'activité protéasome constitutive. Dans certains modes de réalisation, l'invention concerne le traitement de maladies immunes, comprenant l'administration d'un composé de l'invention. Dans certains modes de réalisation, l'invention concerne le traitement du cancer, comprenant l'administration d'un composé de l'invention.
Bennett Mark K.
Laidig Guy J.
Parlati Francesco
Shenk Kevin D.
Smyth Mark S.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Proteolix Inc.
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