C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/20 (2006.01) A61K 31/407 (2006.01) A61K 31/4747 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 471/10 (2006.01) C07D 491/107 (2006.01)
Patent
CA 2702995
The present invention relates to compounds of Formula (I), below, (wherein R1, R2, R3, R27, R28, R29, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. Formula (I). [[Chemical formula should be inserted here as it appears in the paper abstract.]
La présente invention porte sur des composés représentés par la Formule (I), ci-après (dans laquelle R1, R2, R3, R27, R28, R29, p, E, le cycle A et le cycle B sont tels que définis présentement). La présente invention porte également sur des compositions (comprenant des compositions pharmaceutiquement acceptables) comprenant ces composés, individuellement ou en combinaison avec un ou plusieurs agents thérapeutiques supplémentaires, et sur des procédés permettant de les utiliser dans l'inhibition de l'activité de la kinésine KSP, et pour traiter des maladies ou troubles de la prolifération cellulaire associés avec l'activité de la kinésine KSP. Formule (I).
Angeles Angie R.
Dai Chaoyang
Mansoor Umar Faruk
Siddiqui M. Arshad
Vitharana Lalalnthi Dilrukshi
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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