Compounds for the treatment of estrogen-dependent illnesses...

Details Compounds for the treatment of estrogen-dependent illnesses... Compounds for the treatment of estrogen-dependent illnesses...

C - Chemistry, Metallurgy

07

C

C07C 307/02 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61P 5/30 (2006.01)

Patent

CA 2345988

Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of an estrogen-dependent disease are also disclosed.

Cette invention a trait à de nouveaux composés, bloquant le récepteur d'oestrogène et/ou inhibant la sulfatase, utilisés pour le traitement de maladies liées aux oestrogènes. Ces composés renferment, d'ordinaire, une fraction sulfamate et une fraction aromatique bloquant le récepteur d'oestrogène. Elle porte également sur des procédés de synthèse de ces composés et sur l'utilisation qui en est faite pour le traitement et la prévention de maladies liées aux oestrogènes.

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