C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/04 (2006.01) A61P 31/04 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2745787
Compounds of formula (I), or formula (II) or a pharmaceutically acceptable salt of formula (I) or formula (II), wherein: R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl; R2 is methyl or haloalkyl; R4 is hydroxyl, carbonyloxy, or carbonyldioxy; and R3 is aliphatic, aryl, aralkyl, or alkylaryl; and R5, R6, R7 and R8 are each individually H, halogen, alkoxy, alkyl, haloalkyl, aryl, nitro, cyano, amino, amido, acyl, carboxyl, substituted carboxyl, or -SO2R10, wherein R10 is H, alkyl, amino or haloalkyl; provided that in formula (I), R5 and R7 are not both H or R6 is not H or methoxy; and in formula (II) that if R4 is carbonyldioxy then R7 is not methoxy.
L'invention porte sur des composés de formule (I), ou de formule (II) ou sur un sel pharmaceutiquement acceptable de formule (I) ou de formule (II), où : R1 représente H, hydroxyle, alcoxy, acyle, alkyle, cycloalkyle, aryle, ou hétéroaryle; R2 représente méthyle ou haloalkyle; R4 représente hydroxyle, carbonyloxy, ou carbonyldioxy; et R3 représente aliphatique, aryle, aralkyle, ou alkylaryle; et R5, R6, R7 et R8 représente chacun individuellement H, halogène, alcoxy, alkyle, haloalkyle, aryle, nitro, cyano, amino, amido, acyle, carboxyle, carboxyle substitué, ou -SO2R10, où R10 représente H, alkyle, amino ou haloalkyle; à la condition que dans la formule (I), R5 et R7 ne représentent pas tous deux H ou R6 ne représente pas H ou méthoxy; et que, dans la formule (II), si R4 représente carbonyldioxy, alors R7 ne représente pas méthoxy.
Burrows Jeremy
Cross Richard M.
Flanigan David L.
Hinrichs David J.
Kelly Jane X.
Medicines For Malaria Venture
Oregon Health & Science University
Smart & Biggar
The Government Of The United States Of America D.b.a.the Departm
University Of South Florida
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