Compounds that bind to the interferon-gamma, preparation...

Details Compounds that bind to the interferon-gamma, preparation... Compounds that bind to the interferon-gamma, preparation...

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 31/727 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) C08G 65/00 (2006.01) C08G 65/32 (2006.01) C08G 81/00 (2006.01)

Patent

CA 2489561

The invention relates to a compound that can bind to the interferon-gamma (IFN?), which is selected from molecules having formula (I), in which X denotes a divalent spacer group having a sufficient length to enable each of the two oligosaccharide fragments A and B to bind to one of the peptide sequences 125 to 143 at the C-terminal ends of a homodimer of interferon-? (IFN-?) and n denotes an integer of between 0 and 10, e.g. equal to 0, 1, 2, 3, 4 or 5, and each R denotes independently a hydrogen atom, an SO¿3??- ¿group, or phosphate, on the condition that no SO¿3??-¿group is located in position 3 of the glucosamine units of the compound (I). The invention also relates to the method of preparing the compounds, the complexes formed by the aforementioned compounds and the interferon-gamma and medicaments containing said compounds or complexes.

Composé susceptible de se lier à l'interféron gamma (IFN.gamma.) choisi parmi les molécules répondant à la formule (I) suivante: dans laquelle X est un groupe espaceur divalent d'une longueur suffisante pour permettre aux deux fragments oligosaccharides A et B de se lier chacun à l'une des séquences peptidiques 125 à 143 des extrémités C-terminales d'un homodimère d'interféron .gamma. (IFN-.gamma.) et n représente un nombre entier de 0 à 10, par exemple égal à 0, 1, 2, 3, 4 ou 5 et chaque R représente indépendamment un atome d'hydrogène un groupe SO3-, ou phosphate, à la condition qu'aucun groupe SO3- ne se trouve en position 3 des unités glucosamines du composé (I). L'invention concerne également le procédé de préparation de ces composés, les complexes formés par ces composés et l'interféron gamma, et les médicaments comprenant ces composés ou complexes.

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