C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2236868
The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, the use of such a host cell to screen drugs. The methods include the prophylactic and therapeutic treatment of viral infection, in particular HIV infection, and, thus, are also directed to viral vaccines and the treatment of cancer, in particular cancer of viral etiology. Other methods include the use of such conditionally replicating viral vectors in gene therapy and other applications.
L'invention concerne un vecteur viral à réplication conditionnelle, des procédés de préparation, de modification, de propagation et de conditionnement sélectif, ainsi que d'utilisation de ce vecteur, des molécules isolées de séquences spécifiques de nucléotides et d'acides aminés relatives à ces vecteurs, une composition pharmaceutique et une cellule hôte comprenant ce vecteur, l'utilisation de cette cellule hôte afin de cribler des médicaments. Ces procédés consistent à effectuer le traitement prophylactique et thérapeutique de l'infection virale, en particulier, de l'infection par HIV, et, de ce fait, s'adressent également à des vaccins viraux et au traitement du cancer, en particulier, au cancer d'étiologie virale. D'autres procédés consistent à utiliser ces vecteurs viraux à réplication conditionnelle en thérapie génique et dans d'autres mises en application.
Dropulic Boro
Pitha Paula M.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Johns Hopkins University
The Johns Hopkins University School Of Medicine
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