Conditionally replicating viral vectors and their use

Details Conditionally replicating viral vectors and their use Conditionally replicating viral vectors and their use

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) A61P 31/00 (2006.01) A61P 31/14 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01) C12Q 1/04 (2006.01) C12Q 1/18 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2422544

The present invention provides improved conditionally replicating vectors that have improved safety against the generation of replication competent vectors or virus. Also disclosed are methods of making, propagating and selectively packaging, modifying, and using such vectors. Included are improved helper constructs, host cells, for use with the improved vectors as well as pharmaceutical compositions and host cells comprising the vectors, the use of vector containing host cells to screen drugs, and methods of using the vectors to determine gene function. The methods also include the prophylatic and therapeutic treatment of disease, especially viral infection, and HIV infection in particular.

L'invention concerne des vecteurs améliorés à réplication conditionnelle présentant une protection accrue contre la génération vecteurs ou virus capables de réplication. L'invention concerne également de procédés de préparation, de propagation et d'encapsidation sélective, de modification et d'utilisation de tels vecteurs. L'invention concerne notamment des assistants recombinés, des cellules hôtes destinés à être utilisés avec ces vecteurs améliorés, ainsi que des compositions pharmaceutiques et des cellules hôtes comprenant ces vecteurs, l'utilisation de cellules hôtes contenant les vecteurs pour l'identification de médicaments, et des procédés consistant à utiliser ces vecteurs pour déterminer une fonction génique. Les méthodes décrites comprennent en outre le traitement préventif et curatif de maladies, en particulier d'infections virales et de l'infection par le VIH.

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