A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/704 (2006.01) A61K 31/337 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 45/00 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2447023
Conjugates, compositions and method for treatment, prevention, or amelioration of one or more symptoms of cell surface protease-related diseases, including MTSP-related, urokinase-type plasminogen activator (uPA) or endotheliase- related diseases, are provided. The conjugates for use in the compositions and methods are peptidic conjugates that contain therapeutic, including cytotoxic, agents.
La présente invention concerne des conjugués, des compositions et un procédé de traitement, de prévention, ou d'amélioration d'un ou des symptômes des maladies associées à la protéase des surfaces cellulaires, y compris les maladies associées à la sérine protéase membranaire, à l'activateur du plasminogéne de type urokinase, ou à l'endothéliase. Les conjugués utilisés dans les compositions et procédés sont des conjugués peptidiques qui contiennent des agents thérapeutiques, y compris des agents cytotoxiques.
Kemp Scott Jeffrey
Komandla Mallareddy
Madison Edwin L.
Semple Joseph Edward
Siev Daniel Vanna
Dendreon Corporation
Dendreon San Diego Llc
Smart & Biggar
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