C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 167/130,
C12N 15/62 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/73 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2000989
ABSTRACT This invention relates to compositions and methods useful for the treatment and prevention of acquired immunodeficiency syndromes (AIDS), AIDS related complex (ARC), and human immunodeficiency virus (HIV) infection. More particularly, this invention relates to immunotoxins formed by conjugating a toxin to a soluble T4 protein, an HIV virus receptor that binds to the HIV virus or to target cell carrying the gp120/160 HIV marker. This invention also relates to methods for secreting soluble T4-toxin fusion protein conjugates through the cell membrane of a host. The compositions and methods of this invention advantageously provide a highly specific, site-directed delivery system for delivery of toxin to HIV infected cells and to circu- lating HIV virus.
Gates Liora L.
Lobb Roy R.
Meade Harry M.
Winkler Gunther
Biogen Inc.
Biogen Idec Ma Inc.
Gates Liora L.
Lobb Roy R.
Meade Harry M.
LandOfFree
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