C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 27/06 (2006.01) A61P 35/04 (2006.01) C12N 5/12 (2006.01)
Patent
CA 2526509
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
L'invention concerne des anticorps qui se lient au facteur de croissance du tissu conjonctif (CTGF). Ces anticorps sont particulièrement dirigés contre des régions du CTGF impliquées dans des activités biologiques associées à la fibrose. L'invention concerne également des procédés d'utilisation desdits anticorps pour le traitement de troubles associés au CTGF, y compris des troubles fibrotiques localisés et systémiques, notamment ceux du poumon, du foie, du coeur, de la peau et du rein.
Lin Ai Y.
Neff Thomas B.
Oliver Noelynn A.
Usinger William R.
Wang Qingjian
Fibrogen Inc.
Smart & Biggar
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