Conotoxins having acetylcholin receptor binding properties

Details Conotoxins having acetylcholin receptor binding properties Conotoxins having acetylcholin receptor binding properties

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2165566

Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.

Toxines de cône sensiblement pures pouvant inhiber les transmnissions synaptiques au niveau des jonctions neuro-musculaires, et étant utilisables à la fois in vivo et dans les dosages car elles ciblent de manière spécifique certains récepteurs particuliers tels que le récepteur d'acétylcholine, ainsi que les canaux ioniques. La longueur des peptides est telle qu'on peut les produire par synthèse chimique. On peut également les produire à l'aide de techniques d'ADN recombiné, et l'ADN codant les toxines de cône de ce type et présentant des propriétés pesticides peut être intégré, à titre de gènes phytoprotecteurs, aux espèces végétales à protéger.

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