Continuous selective clonogenic expansion of relatively...

Details Continuous selective clonogenic expansion of relatively... Continuous selective clonogenic expansion of relatively...

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) C07K 16/28 (2006.01) C12M 3/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2221623

A system is provided for selective clonogenic expansion of relatively undifferentiated cells, including (a) a tube containing a plurality of beads of a size which permits a plurality of the undifferentiated cells to grow thereon (Figure 1), the beads bearing on their surfaces a selective binding molecule which binds to a surface antigen present on the relatively undifferentiated cells (Figure 1A), wherein the antigen is not present on the surfaces of the relatively differentiated cells; (b) means for continuously providing nutrients to the relatively undifferentiated cells growing on the beads, wherein the nutrients are delivered via a fluid which flows through the tube and past the beads (Figure 1); and (c) means for continuously harvesting the relatively undifferentiated cells downstream of the beads (Figure 1).

Système permettant d'effectuer le développement par clonage de cellules relativement non différenciées, comprenant (a) un tube contenant une pluralité de billes dont la taille permet à plusieurs des cellules non différenciées de se développer sur elles (figure 1), les billes étant porteuses d'une molécule de liaison sélective située sur leur surface, qui se lie à un antigène de surface présent sur les cellules relativement non différenciées (figure 1A), l'antigène n'étant pas présent sur la surface des cellules relativement différenciées; (b) un dispositif qui fournit en continue des substances nutritives aux cellules non différenciées qui se développent sur les billes, lesdites substances nutritives étant apportées par l'intermédiaire d'un fluide qui s'écoule dans le tube et sur les billes (figure 1); et (c) un dispositif qui recueille en continu les cellules relativement non différenciées en aval des billes (figure 1).

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