Controlled release drug formulation

Details Controlled release drug formulation Controlled release drug formulation

A - Human Necessities

61

M

A61M 37/00 (2006.01) A61K 9/00 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2139058

A drug formulation for producing sustained therapeutic efficacy, which releases water-soluble drug intracorporeally over a prolonged period of time at a substantially constant rate wherein said drug formulation comprises (a) a nondisintegrating inner layer comprised of a biocompatible material that contains uniformly dispersed water-soluble drug; and (b) an outer layer comprised of a biocompatible material that surrounds the circumference of the said inner layer, is impermeable to water, and is capable of controlling the swelling of the inner layer; wherein the ratio of the axial length of the drug formulation to the cross-sectional diameter of the inner layer is one or more and one or both ends of the inner layer are open so as to come into direct contact with the external environment.

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