Coumpounds of the formula r1-x-y-z-nr2r3 as abca-1 elevating...

Details Coumpounds of the formula r1-x-y-z-nr2r3 as abca-1 elevating... Coumpounds of the formula r1-x-y-z-nr2r3 as abca-1 elevating...

C - Chemistry, Metallurgy

07

C

C07C 237/40 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/351 (2006.01) A61K 31/4406 (2006.01) A61K 31/53 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) C07C 233/07 (2006.01) C07C 235/24 (2006.01) C07C 237/04 (2006.01) C07C 237/06 (2006.01) C07C 237/22 (2006.01) C07C 237/38 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07C 311/20 (2006.01) C07C 323/36 (2006.01) C07C 323/40 (2006.01) C07C 323/60 (2006.01) C07C 327/42 (2006.01) C07C 327/48 (2006.01) C07C 335/16 (2006.01) C07D 211/5

Patent

CA 2431005

The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.

L'invention concerne des composés qui développent l'expression cellulaire du gène ABCA-1, favorisent l'élimination du cholestérol des cellules et augmentent les niveaux de lipoprotéine à densité élevée dans le plasma d'un animal, en particulier un animal humain. Ces composés sont utilisés pour traiter la coronaropathie.

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