Crf binding protein

G - Physics – 01 – N

Patent

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Details

G01N 33/577 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2147875

Corticotropin Releasing Factor-binding protein (CRF-BP) is produced recombinantly and is useful for modulating the bio- logical activity of CRF. CRF-BP or fragments thereof and/or antibodies to the proteins are employed in diagnostic assays to de- termine the levels of CRF, CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. Following such an assay, CRF-BP can be effectively employed to treat pregnancy-related pathological disorders by lowering the ratio of CRF/CRF-BP to within a normal range for pregnancy. The anti-CRF-BP antibodies are also useful to purify the CRF-BP and to modulate the biological effect of CRF-BPs.

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