Cross-linked bioactive hydrogel matrices

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/52 (2006.01) A61K 9/00 (2006.01) A61L 27/26 (2006.01) A61L 27/44 (2006.01) A61L 27/20 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2476653

The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.

La présente invention concerne une matrice d'hydrogel réticulé stabilisé comprenant un premier composant de poids moléculaire élevé et un second composant de poids moléculaire élevé liés par covalence, et au moins un agent de stabilisation ou d'activation, le premier composant de poids moléculaire élevé et le second composant de poids moléculaire élevé étant chacun sélectionné dans le groupe comprenant les polyglycanes et les polypeptides. Cette matrice d'hydrogel stabilisé peut former un gel, une pâte, une suspension épaisse ou un squelette de liaison cellulaire bioactifs pour dispositifs médicaux implantables, et des matériaux de coulage et de liaison adaptés pour l'élaboration de dispositifs médicaux. La bioactivité intrinsèque de la matrice d'hydrogel permet de l'utiliser en tant que gel ou pâte dans de multiples applications, y compris un squelette de liaison cellulaire favorisant la cicatrisation de la blessure autour d'un dispositif implanté, et en tant que gel ou pâte induisant une vasculogenèse localisée, la cicatrisation des blessures, la réparation et la régénération tissulaire, en tant qu'adhésif pour blessures, et pour la prolifération tissulaire.

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