Crystal structure of erbb2 and uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/475 (2006.01) C07K 14/71 (2006.01) C07K 14/82 (2006.01)

Patent

CA 2500288

More particularly, the present invention relates to the crystal structure of the ErbB2, in particular the crystal structure of an extracellular portion of ErbB2 and to methods of using the crystal and related structural information to screen for and design compounds that interact with ErbB2, or variants of thereof.

La présente invention se rapporte plus particulièrement à la structure cristalline de ErbB2, notamment à la structure cristalline d'une partie extracellulaire de ErbB2. Cette invention concerne également des procédés d'utilisation du cristal et des informations de structure associées afin de cribler et de mettre au point des composés qui interagissent avec ErbB2 ou avec des variants de ErbB2.

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