C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C07K 7/06 (2006.01) C30B 29/58 (2006.01) G01N 23/20 (2006.01) G01N 23/207 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2407545
EP0105854nt invention relates to the crystal and three dimensional structures of the lectin and EGF-like (LE) domains of P-selectin, the crystal and three dimensional structures of P-selectin LE and E-selectin LE each complexed with SLeX, as well as the crystal and three dimensional structure of P-selectin LE complexed with a functional PSGL-1 peptide modified by both tyrosine sulfation and SLeX. The present invention also provides methods for identifying agents which activate or inhibitor each of the foregoing structures. In addition, the present invention provides agents identified by such methods.
L'invention concerne les structures cristallines en trois dimensions des domaines lectine et des domaines lectine (LE) de type EGF de la sélectine P. L'invention concerne également les structures cristallines et en trois dimensions de la sélectine P LE et de la sélectine E LE chacune complexée à l'aide de SLe?X¿, ainsi que la structure cristalline en trois dimensions de la sélectine P LE complexée à l'aide d'un peptide PSGL-1 fonctionnel à la fois par sulfatation de la tyrosine et par SLe?X¿. L'invention concerne également des procédés permettant d'identifier les agents activant ou inhibant chacune des structures susmentionnées, et les agents identifiés grâce à ces procédés.
Camphausen Raymond
Seehra Jasbir
Somers William S.
Tang Jin
Genetics Institute Llc
Torys Llp
LandOfFree
Crystal structures of p-selectin, p- and e-selectin... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystal structures of p-selectin, p- and e-selectin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystal structures of p-selectin, p- and e-selectin... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1634256