Crystalline forms of dimethoxy docetaxel and methods for...

C - Chemistry – Metallurgy – 07 – D

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C07D 305/14 (2006.01)

Patent

CA 2712373

The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2a-benzoyloxy-5ß,20-epoxy-l-hydroxy-7ß,10ß-dimethoxy-9-oxo-tax-l l- ene-13a-yle, and to the preparation thereof.

Anhydres, solvats et hétéro-solvats éthanoliques, hydrates du diméthoxy docétaxel ou (2R,3S)-3-tert-butoxycarbonylamino -2-hydroxy-3-phényl-propionate de 4-acétoxy-2.alpha.-benzoyloxy-5.beta.,20- époxy-1-hydroxy-7.beta.,10.beta.-diméthoxy-9- oxo-tax-11- ène-13.alpha.-yle et leur préparation

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