C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) C30B 29/58 (2006.01) G01N 23/20 (2006.01) G01N 33/53 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2477980
The crystal structure of human MAPKAP kinase-2 is described, including the high-resolution X-ray diffraction structure and atomic structure coordinates obtained therefrom. A method of crystallization of MK-2 involving the use of a crystallization additive and the specific empirical conditions involved in this crystallization method is also described. This method of crystallization allows a resolution of about 3 Angstroms to be achieved. The tertiary structure of this protein as determined by X-ray crystallography to a resolution of 3 Angstroms is shown. Also described are methods by which the atomic structural information obtained from the MK-2 crystals can be used to screen for, identify and/or design new drugs.
L'invention porte sur la structure des cristaux de la mapkap kinase-2 humaine y compris les coordonnées de la structure de diffraction à haute résolution aux rayons X, et de la structure atomique, en étant obtenue. L'invention porte également sur un procédé de cristallisation de la MK-2 comprenant l'utilisation d'un additif de cristallisation et les conditions empiriques spécifiques utilisées dans ledit procédé de cristallisation qui permet d'obtenir une résolution d'environ 3 Angströms. L'invention porte en outre sur un procédé d'utilisation des informations sur la structure atomique obtenues à partir des cristaux de MK-2, pour le criblage, l'identification, et/ou la mise au point de nouveaux médicaments.
Bolten Suzanne L.
Broadus Richard M.
Kurumbail Ravi G.
Mourey Robert J.
Pawlitz Jennifer L.
Pharmacia Corporation
Smart & Biggar
LandOfFree
Crystalline structure of human mapkap kinase-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystalline structure of human mapkap kinase-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline structure of human mapkap kinase-2 will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1386357