Cxcr4 antagonists for the treatment of hiv infection

Details Cxcr4 antagonists for the treatment of hiv infection Cxcr4 antagonists for the treatment of hiv infection

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2593612

The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry of certain viruses. Certain compounds in particular can reduce entry of immunodeficiency virus (HIV) into a cell while not reducing the capacity of stem cells to proliferate, and therefore can be useful for long term treatment regimes. The compounds are useful in particular in the treatment or prevention of HIV infections.

Composés, compositions pharmaceutiques et procédés d'utilisation de certains composés qui sont des antagonistes du récepteur CXCR4 de chimiokine, en particulier pour inhiber l'entrée virale de certains virus. Certains composés en particulier peuvent réduire l'entrée du virus d'immunodéficience (VIH) dans une cellule, tout en ne réduisant pas la capacité des cellules souches à proliférer, ce qui les rend utiles pour des traitements à long terme. Lesdits composés sont utiles en particulier pour traiter ou prévenir les infections dues au VIH.

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