Cyclic amine compounds as ccr5 antagonists

Details Cyclic amine compounds as ccr5 antagonists Cyclic amine compounds as ccr5 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61P 31/18 (2006.01) C07D 211/62 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2608807

A compound of formula (I): (see formula I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R1 and R2 may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N+ -R5.cndot.Y- (R5 is a hydrocarbon group; Y- is a counter anion); R3 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4 is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1 is a bond, CO or SO2; G2 is CO, SO2, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3 aliphatic hydrocarbon which may be substituted; provided that J is methane when G2 is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G1 is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).

Affiliated with

Also associated with

Rating

Cyclic amine compounds as ccr5 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic amine compounds as ccr5 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic amine compounds as ccr5 antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1598466