Cyclic amine derivatives for inhibiting blood platelet...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 211/72 (2006.01) A61K 31/397 (2006.01) A61K 31/445 (2006.01) C07D 205/04 (2006.01) C07D 207/08 (2006.01) C07D 207/12 (2006.01) C07D 211/20 (2006.01) C07D 211/54 (2006.01) C07D 213/70 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01)

Patent

CA 2263983

Cyclic amine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, excellent in the effect of inhibiting platelet aggregation and useful as a preventive or remedy for embolism, thrombosis or arteriosclerosis, wherein R1 represents optionally substituted phenyl; R2 represents optionally substituted C1 -C8 acyl, optionally substituted benzoyl or C1 -C4 alkoxycarbonyl; and R3 represents optionally fused, substituted three- to seven-membered cyclic saturated amino.

L'invention concerne des dérivés cycliques d'amines représentés par la formule générale (I), ou des sels de ceux-ci acceptables sur le plan pharmacologique. Ces dérivés sont excellents pour empêcher l'agrégation plaquettaire et sont utiles pour prévenir ou soigner l'embolie, la thrombose ou l'artériosclérose. Dans ladite formule (I), R<1> représente phényle éventuellement substitué; R<2> représente acyle C1-C8 éventuellement substitué, benzoyle éventuellement substitué ou alcoxycarbonyle C1-C4; et R<3> représente un amino saturé cyclique éventuellement condensé, substitué et composé de 3 à 7 éléments.

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