Cyclic amine modulators of chemokine receptor activity

Details Cyclic amine modulators of chemokine receptor activity Cyclic amine modulators of chemokine receptor activity

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 211/18 (2006.01) C07D 211/32 (2006.01) C07D 211/36 (2006.01) C07D 211/56 (2006.01) C07D 211/96 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 407/14 (2006.01) C07D 409/06 (2006.01) C07D 409/10 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01) C07D 491/107 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2319781

The present invention is directed to cyclic amines of formula I (wherein R1, R2, R3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR- 4, CCR-5, CXCR-3, and/or CXCR-4.

Cette invention concerne des amines cycliques de formule (I). Dans la formule (I), R?1¿,R?2¿, R?3¿, m et n sont tels que dans le descriptif. Ces amines cycliques sont utiles en tant que modulateurs de l'activité du récepteur de chémokine, et de manière plus spécifique elles sont utiles en tant que modulateurs des récepteurs de chémokine CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3 et/ou CXCR-4.

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