C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/10 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2712500
This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie),(If), (Ig), (Ih), (Ti), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11.beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Cette invention concerne de nouveaux composés de Formule (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), les sels pharmaceutiquement acceptables de ceux-ci et des compositions pharmaceutiques les contenant, qui sont utiles pour le traitement thérapeutique des maladies associées à la modulation ou à l'inhibition de la 11ß-HSD1 chez le mammifère. L'invention concerne, en outre, des compositions pharmaceutiques à base des nouveaux composés et des procédés pour leur utilisation en vue de réduire ou de gérer la production de Cortisol dans une cellule ou d'inhiber la conversion de la cortisone en Cortisol dans une cellule.
Cacatian Salvacion
Claremon David A.
Singh Suresh B.
Tice Colin M.
Ye Yuanjie
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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