Cyclic hexapeptide oxytocin antagonists

Details Cyclic hexapeptide oxytocin antagonists Cyclic hexapeptide oxytocin antagonists

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) C07K 7/16 (2006.01)

Patent

CA 2036973

8/TGR4 13/TGR5 14/TGR6 24/TGR8 17892 TITLE OF THE INVENTION CYCLIC HEXAPEPTIDE OXYTOCIN ANTAGONISTS ABSTRACT OF THE DISCLOSURE Disclosed are cyclic hexapeptides of the formula : Image I 8/TGR4 13/TGR5 14/TGR6 24/TGR8 -i- 17892 These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarian delivery. Also disclosed are pharmaceu- tical compositions containing the compounds of formula I and methods of preparing these compounds.

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