C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61P 3/00 (2006.01)
Patent
CA 2750517
This invention relates to novel compounds of an 11 .beta.-HSD1 inhibitor disclosed herein, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11/3-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
La présente invention concerne de nouveaux composés d'un inhibiteur de 11ß-HSD1, des sels pharmaceutiquement acceptables de celui-ci, et des compositions pharmaceutiques de celui-ci, utiles dans le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de 11/3-HSD1 chez des mammifères. L'invention concerne en outre des compositions pharmaceutiques de ces nouveaux composés et des méthodes d'utilisation afférentes, dans la réduction ou dans la régulation de la production de cortisol dans une cellule ou de l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Claremon David A.
Leftheris Katerina
Singh Suresh B.
Tice Colin M.
Ye Yuanjie
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