Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

Details Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/5355 (2006.01) A61P 19/10 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2730499

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11.beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

Cette invention concerne de nouveaux composés de formule Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, leurs sels pharmaceutiquement acceptables et leurs compositions pharmaceutiques, qui sont utilisés en traitement thérapeutique des maladies associées avec la modulation ou linhibition de la 11ß-HSD1 chez le mammifère. Linvention concerne par ailleurs des compositions pharmaceutiques des nouveaux composés et leurs procédés dutilisation dans la réduction ou le contrôle de la production du cortisol dans une cellule ou linhibition de la conversion de la cortisone en cortisol dans une cellule.

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