C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 407/14 (2006.01) C07D 413/14 (2006.01) C07D 471/10 (2006.01)
Patent
CA 2747677
The present invention relates to novel antagonists for CCR2(CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single bond, =CH-, -CH2-, -O-, -S-, and -NH-; wherein n is 1, 2 or 3; wherein Z is C or N, the other variables are as defined in the claims, as well as in form of their acid addition salts with pharmacologically acceptable acids.
Cette invention concerne de nouveaux antagonistes de CCR2 (récepteur 2 de chimiokine CC) et leur utilisation dans des médicaments destinés au traitement d'états pathologiques et de maladies, en particulier de l'asthme et les broncho-pneumopathies chroniques obstructives, comme représenté dans la Formule (I), où A est pris dans une liaison unique, =CH-, -CH2-, -O-, -S-, and -NH-; n vaut 1, 2 ou 3; Z est C ou N, les autres variables étant comme définies dans les revendications, ainsi que leurs formes de sels d'adjonction acides avec des acides de qualité pharmacologique.
Buettner Frank
Ebel Heiner
Frattini Sara
Giovannini Riccardo
Hobbie Silke (marie Katrin)
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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