Cyclic renin inhibitors containing...

Details Cyclic renin inhibitors containing... Cyclic renin inhibitors containing...

C - Chemistry, Metallurgy

07

K

260/272, 530/5.0

C07K 5/065 (2006.01) C07D 245/02 (2006.01) C07D 273/00 (2006.01) C07D 273/02 (2006.01) C07D 281/00 (2006.01) C07D 285/00 (2006.01) C07D 291/02 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 419/12 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01) C07F 9/547 (2006.01) C07F 9/6527 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01) C07K 5/02 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2031735

4/MD3 5/MD4 6/MD5 7/MD6 17785IB TITLE OF THE INVENTION CYCLIC RENIN INHIBITORS CONTAINING 3(S)-AMINO-4- CYCLOHEXYL-2(R)-HYDROXY-BUTANOIC ACID OR 4-CYCLO- HEXYL-(2R, 3S)-DIHYDROXYBUTANOIC ACID OR RELATED ANALOGS ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image (I) 4/MD3 -i- 17785IB are disclosed. These compounds inhibit the angioten- sinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldo- steronism, congestive heart failure, and glaucoma.

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