Cyclic renin inhibitors

Details Cyclic renin inhibitors Cyclic renin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 245/02 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) C07D 243/00 (2006.01) C07D 255/02 (2006.01) C07D 267/00 (2006.01) C07D 281/00 (2006.01) C07D 321/00 (2006.01) C07D 327/02 (2006.01) C07D 413/00 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070983

87/MRD61 88/MRD62 89/MRD63 90/MRD64 17784IC TITLE OF THE INVENTION CYCLIC RENIN INHIBITORS CONTAINING 2-SUBSTITUTED (3S,4S)-4-AMINO-5-CYCLOHEXYL-3-HYDROXY PENTANOIC ACID, 2-SUBSTITUTED (3S,4S)-5-CYCLOHEXYL-3,4-DI- HYDROXYPENTANOIC ACID OR 2-SUBSTITUTED (4S,5S)-5- AMINO-6-CYCLOHEXYL-4-HYDROXYHEXANOIC ACID OR ITS ANALOGS ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image (I) 87/MRD61 88/MRD62 89/MRD63 90/MRD64 -i- 17784IC are disclosed. These compounds inhibit the angioten- sinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldo- steronism, congestive heart failure, and glaucoma.

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