Cyclization to form cephem ring and intermediates therefor

C - Chemistry – Metallurgy – 07 – D

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C07D 205/08 (2006.01) C07D 205/095 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1132547

ABSTRACT An intermediate represented by the following formula for synthesizing 3-hydroxy-3-cephem compounds: Image wherein A and B are, independently, hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted aralkanoyl or substituted or unsubstituted aroyl; R is thiol group or carboxylic acyl group; X is hydroxy or carboxy-protecting group and the broken line between A and R shows that, when R and B are hydrogens, A is a carboxylic acyl.

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