C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/40 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) A61K 38/04 (2006.01) C07C 233/57 (2006.01) C07C 233/58 (2006.01) C07C 233/59 (2006.01) C07C 233/60 (2006.01) C07C 235/82 (2006.01) C07C 311/45 (2006.01) C07C 317/44 (2006.01) C07C 323/40 (2006.01) C07D 213/56 (2006.01) C07D 215/14 (2006.01) C07D 263/32 (2006.01) C07D 307/54 (2006.01) C07D 317/60 (2006.01) C07D 333/20 (2006.01) C07D 333/24 (2006.01) C07D 333/60 (2006.01)
Patent
CA 2218597
The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
La présente invention se rapporte à un composé de la formule (I) ou (II) ou à un sel pharmaceutiquement acceptable de celui-ci, qui sont utilisés pour l'inhibition de la protéine farnésyltransférase et la farnésylation de la protéine oncogène Ras ou pour l'inhibition de la production de de novo squalène entraînant l'inhibition de la biosynthèse du cholestérol. L'invention se rapporte également à des procédés de préparation de ces composés ainsi qu'aux intermédiaires utilisés dans ces procédés, à une composition pharmaceutique et aux procédés de mise en oeuvre de ces composés.
Arendsen David L.
Augeri David J.
Baker William R.
Fakhoury Stephen A.
Fung K.l. Anthony
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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